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研究テーマ

更新日:2021年3月24日 ページ番号:0000063

放射線発がんの発症機構に関する理論的・実験的研究

Ojima M, Ito A, Usami N, Ohara M, Suzuki K, Kai M: Field size effects on DNA damage and proliferation in normal human cell populations irradiated with X-ray microbeams. Sci Rep. 11(1). doi: 10.1038/s41598-021-86416-7. (2021) 

菓子野元郎, 熊谷純, 有吉健太郎, 小嶋光明:放射線誘発バイスタンダー効果およびレスキュー効果の実態と今後の展望. 放射線生物研究, 56, 19-36 (2021)

Etani R, Ojima M, Ariyoshi K, Fujishima Y, Kai M. Cellular kinetics of hematopoietic cells with Sfpi1 deletion are present at different frequencies in bone-marrow and spleen in X-irradiated mice. Int J Radiat Biol. 96(9), 1119-1124 (2020)

Ojima,M, Hirouchi,T, Etani,R, Ariyoshi,K, Kai,M Dose-rate-dependent PU.1 inactivation to develop acute myeloid leukemia in mice through persistent stem cell proliferation following acute or chronic gamma irradiation. Radiat Res 192, 612-620 (2019)

Ojima M, Iwashita K, Kashino G, Kobashigawa S, Sasano N, Takeshita A, Ban N, Kai M; Early and delayed induction of DSBs by nontargeted effects in ICR mouse lymphocytes after in vivo X irradiation. Radiat Res. 186(1),65-70 (2016)

小嶋光明、廣内篤久;急性骨髄性白血病につながる造血細胞および造血組織の放射線応答.放射線生物研究 51, 34-56 (2016)

Ojima M, Ito M, Suzuki K, Kai M. Unstable Chromosome Aberrations Do Not Accumulate in Normal Human Fibroblast after Fractionated X-Irradiation. Plos One. 19, e0116645 (2015)

小嶋光明、甲斐倫明;低線量域における線量率効果 -二動原体染色体発生頻度に着目して. 放射線生物研究 47(4),347-360 (2012)

甲斐倫明;低線量・低線量率のリスク推定のための理論とデータ. 放射線生物研究 47(4), 379-393 (2012)

Ojima M, Eto H, Ban N, Kai M. Radiation-induced bystander effects induce radioadaptive response by low-dose radiation. Radiat Prot Dosimetry. 146(1-3): 276-9 (2011)

Ojima M, Furutani A, Ban N, Kai M. Persistence of DNA double-strand breaks in normal human cells induced by radiation-induced bystander effect. Radiat Res. 175(1): 90-6(2011)

Ojima M, Furutani A, Ban N, Kai M. Persistence of DNA Double-Strand Breaks in Normal Human Cells Induced by Radiation-Induced Bystander Effect. Radiat Res. 175(1): 90-96 (2011)

Ban N, Kai M. Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia. Br J Cancer. 101(2): 363-71(2009)

Ojima M, Ban N, Kai M. DNA double-strand breaks induced by very low X-ray doses are largely due to bystander effects. Radiat Res. 170(3):365-71(2008)

医療放射線に関する防護・安全に関する研究

Etani R, Yoshitake T, Kai M. Estimating Organ Doses from Pediatric Cerebral Computed Tomography Using the WAZA-ARI Web-Based Calculator. J Radiat Prot Res. 46(1), 1-7, 2021

Matsumoto S, Koba Y, Kohno R, Lee C, Bolch WE, Kai M. Secondary Neutron Doses to Pediatric Patients During Intracranial Proton Therapy. Health Phys. 110, 380-386, 2016

Takahashi F, Sato K, Endo A, Ono K, Ban N, Hasegawa T, Katsunuma Y, Yoshitake T, Kai M. Numerical Analysis of Organ Doses Delivered During Computed Tomography Examinations Using Japanese Adult Phantoms with the WAZA-ARI Dosimetry System. Health Phys. 109(2), 104-112, 2015

Kamei O, Ojima M, Yoshitake T, Ono K, Nishijima K, Kai M. Calculating patient-specific organ doses from adult body CT scan by Monte Carlo analysis using male-individual voxel phantoms. Health Phys. 108, 44-52, 2015.

Ono K, Hiraoka T, Ono A, Komatsu E, Shigenaga T, Takaki H, Maeda T, Ogusu H, Yoshida S, Fukushima K, Kai M ; Low-dose CT scan screening for lung cancer: comparison of images and radiation doses between low-dose CT and follow-up standard diagnostic CT. Springerplus 2:393 (2013)

Ono K, Yoshitake T, Hasegawa T, Ban N and Kai M.Estimation of the number of CT procedures based on a nationwide survey in Japan. Health Phys, 100,491-496 (2011)

Ono K, Ban N, Ojima M, Yoshinaga S, Akahane K, Fujii K, Toyota M, Hamada F, Kouriyama C, Akiba S, Kunugita N, Shimada Y, Kai M. Nationwide survey on pediatric CT among children of public health and school nurses to examine a possibility for a follow-up study on radiation effects. Radiat Prot Dosimetry. 146(1-3):260-2 (2011)

Takahashi F, Sato K, Endo A, Ono K, Yoshitake T, Hasegawa T, Katsunuma Y, Ban N, Kai M; WAZA-ARI: computational dosimetry system for X-ray CT examinations I: Radiation transport calculation for organ and tissue doses evaluation using JM phantom. Radiat Prot Dosimetry 146(1-3),241-243 (2011)

Ban N, Takahashi F, Ono K, Hasegawa T, Yoshitake T, Katsunuma Y, Sato K, Endo A, Kai M; WAZA-ARI: computational dosimetry system for X-ray CT examinations II: Development of web-based system. Radiat Prot Dosimetry 146(1-3),244-247 (2011)

Ban N, Takahashi F, Sato K, Endo A, Ono K, Hasegawa T, Yoshitake T, Katsunuma Y, Kai M; Development of a web-based CT dose calculator: WAZA-ARI. Radiat Prot Dosimetry 147(1-2),333-337 (2011)

放射線防護・リスク評価・リスク論に関する研究

Ishikawa,T., Matsumoto,M., Sato,T., Yamaguchi,I. Kai,M. Internal doses from radionuclides and their health effects following the Fukushima accident. J Radiol. Prot. 38;1253-1268, (2018).

恵谷玲央、甲斐倫明;放射性セシウムCs-137の内部被ばくによる非がん影響 -動物実験から得られた知見. 放射線生物研究 53(1) 55-72 (2018)

Shimada K, Kai M. Calculating disability-adjusted life years (DALY) as a measure of excess cancer risk following radiation exposure. J Radiol. Prot. 35,763-775 (2015).

Kai M. Experience and current issues with recovery management from the Fukushima accident. Annals of the ICRP. 44, 153-161 (2015)

Kai M. Some lessons on radiological protection learned from the accident of the Fukushima Daiichi nuclear power plant. J. Radiol. Prot. 32 N101-5 (2012)