研究内容
PM2.5、飛来黄砂、可塑剤、洗剤など、身の回りの化学物質が、免疫系、生殖系に及ぼす影響について調べています
論文一覧（2011～）
Higuchi S, Yoshida S, Takeo Minematsu T, Hatano Y, Notsu A, Ichinose T. Comparison of the Effects of Bathing and the Dry Technique on the Skin Condition of Early Neonates: A Prospective Observational Study. Ann Dermatol. 2023. 35(4):256-265. doi: 10.5021/ad.22.098.
Akaji S, Sagawa T, Honda A, Miyasaka N, Sadakane K, Ichinose T, Takano H. Post-staining Raman analysis of histological sections following decolorization. Analyst. 2022, 147(20):4473-4479. doi: 10.1039/d2an01138g.
Sadakane K, Ichinose T, Maki T Nishikawa M. Co-exposure of peptidoglycan and heat-inactivated Asian sand dust exacerbates ovalbumin-induced allergic airway inflammation in mice. Inhal Toxicol. 2022;34(9-10):231-243. doi: 10.1080/08958378.2022.2086650.
Hiraku Y, Watanabe J, Kaneko A, Ichinose T, Murata M.MicroRNA expression in lung tissues of asbestos-exposed mice: Upregulation of miR-21 and downregulation of tumor suppressor genes Pdcd4 and Reck. J Occup Health. 2021; 63(1):e12282. doi:10.1002/1348-9585.12282
Shen M, Song Y, Ichinose T, Morita K, Wang D, Arashidani K, Yoshida Y. In vivo immune activation of splenocytes following exposure to tar from Asian sand dust. J Toxicol Environ Health A. 2020; 83(19-20):649-658. doi: 10.1080/15287394.2020.1806160
Yoshida Y, Ichinose T, Shibamoto T. Effects of Fetal Exposure to Heat-Not-Burn Tobacco on Testicular Function in Male Offspring. Biol Pharm Bull. 2020;43(11):1687-1692. doi: 10.1248/bpb.b20-00390.
Ren Y, Ichinose T, He M, Youshida S, Nishikawa M, Sun G. Co-exposure to lipopolysaccharide and desert dust causes exacerbation of ovalbumin-induced allergic lung inflammation in mice via TLR4/MyD88-dependent and -independent pathways. Allergy Asthma Clin Immunol. 2019;15:82. doi: 10.1186/s13223-019-0396-4.
Hasunuma H, Ichinose T, Ueda K, Odajima H, Kanatani K, Shimizu A, Takami A, Takeuchi A, Nishiwaki Y, Watanabe M, Hashizume M. [Health Effects of Asian Dust Events: A Literature Review Update of Epidemiological Evidence]. Nihon Eiseigaku Zasshi. 2019;74(0). doi: 10.1265/jjh.19010.
He M, Ichinose T, Ito T, Toriba A, Yoshida S, Sadakane K, Nishikawa M, Sun G, Shibamoto T. Investigation of inflammation inducing substances in PM2.5 particles by an elimination method using thermal decomposition. Environ Toxicol. 2019 Oct;34(10):1137-1148. doi: 10.1002/tox.22816.
He M, Ichinose T, Yoshida S, Nishikawa M, Sun G, Shibamoto T. Role of iron and oxidative stress in the exacerbation of allergic inflammation in murine lungs caused by urban particulate matter <2.5 μm and desert dust. J Appl Toxicol. 2019 Jun;39(6):855-867. doi: 10.1002/jat.3773.
Sadakane K, Ichinose T, Nishikawa M. Effects of co-exposure of lipopolysaccharide and β-glucan (Zymosan A) in exacerbating murine allergic asthma associated with Asian sand dust. J Appl Toxicol. 2019 Apr;39(4):672-684. doi: 10.1002/jat.3759.
Song Y, Ichinose T, Morita K, Yoshida Y. The toll like receptor 4-myeloid differentiation factor 88 pathway is essential for particulate matter-induced activation of CD4-positive cells. J Appl Toxicol. 2019 Feb;39(2):354-364. doi: 10.1002/jat.3726.
He C, Song Y, Ichinose T, He M, Morita K, Wang D, Kanazawa T, Yoshida Y. Lipopolysaccharide levels adherent to PM2.5 play an important role in particulate matter induced-immunosuppressive effects in mouse splenocytes. J Appl Toxicol. 2018 Apr;38(4):471-479. doi: 10.1002/jat.3554.
Yanagisawa R, Koike E, Win-Shwe TT, Ichinose T, Takano H. Effects of lactational exposure to low-dose BaP on allergic and non-allergic immune responses in mice offspring. J Immunotoxicol. 2018 Dec;15(1):31-40. doi: 10.1080/1547691X.2018.1442379. PubMed PMID: 29482396.
He M, Ichinose T, Yoshida Y, Arashidani K, Yoshida S, Takano H, Sun G, Shibamoto T. Urban PM2.5 exacerbates allergic inflammation in the murine lung via a TLR2/TLR4/MyD88-signaling pathway. Sci Rep. 2017
He M, Ichinose T, Yoshida S, Ito T, He C, Yoshida Y, Arashidani K, Takano H, Sun G, Shibamoto T. PM2.5-induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells. J Appl Toxicol. 2017
Hiraku Y, Nishikawa Y, Ma N, Afroz T, Mizobuchi K, Ishiyama R, Matsunaga Y, Ichinose T, Kawanishi S, Murata M. Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells. Mutat Res. 2017
Chowdhury PH, Kitamura G, Honda A, Sawahara T, Hayashi T, Fukushima W, Kudo H, Ito S, Yoshida S, Ichinose T, Ueda K, Takano H. Synergistic effect of carbon nuclei and polyaromatic hydrocarbons on respiratory and immune responses. Environ Toxicol. 2017
Honda A, Sawahara T, Hayashi T, Tsuji K, Fukushima W, Oishi M, Kitamura G, Kudo H, Ito S, Yoshida S, Ichinose T, Ueda K, Takano H. Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma. J Appl Toxicol. 2017
He M, Ichinose T, Yoshida S, Shiba F, Arashidani K, Takano H, Sun G, Shibamoto T. Differences in allergic inflammatory responses in murine lungs: comparison of PM2.5 and coarse PM collected during the hazy events in a Chinese city. Inhal Toxicol. 2016
Yoshida S, Ichinose T, Arashidani K, He M, Takano H, Shibamoto T. Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring. Int J Environ Res Public Health. 2016
Sadakane K, Ichinose T, Nishikawa M, Takano H, Shibamoto T. Co-exposure to zymosan A and heat-inactivated Asian sand dust exacerbates ovalbumin-induced murine lung eosinophilia. Allergy Asthma Clin Immunol. 2016
Honda A, Sawahara T, Hayashi T, Tsuji K, Fukushima W, Oishi M, Kitamura G, Kudo H, Ito S, Yoshida S, Ichinose T, Ueda K, Takano H. Biological factor related to Asian sand dust particles contributes to the exacerbation of asthma. J Appl Toxicol. 2017
Bekki K, Ito T, Yoshida Y, He C, Arashidani K, He M, Sun G, Zeng Y, Sone H, Kunugita N, Ichinose T. PM2.5 collected in China causes inflammatory and oxidative stress responses in macrophages through the multiple pathways. Environ Toxicol Pharmacol. 2016
He M, Ichinose T, Yoshida S, Takano H, Nishikawa M, Shibamoto T, Sun G. Exposure to bisphenol A enhanced lung eosinophilia in adult male mice. Allergy Asthma Clin Immunol. 2016
Yanagisawa R, Koike E, Win-Shwe TT, Ichinose T, Takano H. Low-dose benzo[a]pyrene aggravates allergic airway inflammation in mice. J Appl Toxicol. 2016
He M, Ichinose T, Kobayashi M, Arashidani K, Yoshida S, Nishikawa M, Takano H, Sun G, Shibamoto T. Differences in allergic inflammatory responses between urban PM2.5 and fine particle derived from desert-dust in murine lungs. Toxicol Appl Pharmacol. 2016
He M, Ichinose T, Song Y, Yoshida Y, Bekki K, Arashidani K, Yoshida S, Nishikawa M, Takano H, Shibamoto T, Sun G.. Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway. Toxicol Appl Pharmacol. 2016
He M, Ichinose T, Song Y, Yoshida Y, Kobayashi F, Maki T, Yoshida S, Takano H, Shibamoto T, Sun G: The Role of Toll-Like Receptors and Myeloid Differentiation Factor 88 in Bjerkandera adusta-Induced Lung Inflammation. Int Arch Allergy Immunol. 2015
He M, Ichinose T, Ren Y, Song Y, Yoshida Y, Arashidani K, Yoshida S, Nishikawa M, Takano H, Sun G: PM2.5-rich dust collected from the air in Fukuoka, Kyushu, Japan, can exacerbate murine lung eosinophilia. Inhal Toxicol. 2015
Takeshita S, Tokunaga T, Tanabe Y, Arinami T, Ichinose T, Noguchi E: Asian sand dust aggregate causes atopic dermatitis-like symptoms in Nc/Nga mice. Allergy Asthma Clin Immunol. 2015
Sadakane K, Ichinose T: Effect of the hand antiseptic agents benzalkonium chloride, povidone-iodine, ethanol, and chlorhexidine gluconate on atopic dermatitis in NC/Nga mice. Int J Med Sci. 2015
Michikawa T, Ueda K, Takeuchi A, Kinoshita M, Hayashi H, Ichinose T, Nitta H: Impact of short-term exposure to fine particulate matter on emergency ambulance dispatches in Japan. J Epidemiol Community Health. 2015
Ren Y, Ichinose T, He M, Arashidani K, Yoshida Y, Yoshida S, Nishikawa M, Takano H, Sun G, Shibamoto T: Aggravation of ovalbumin-induced murine asthma by co-exposure to desert-dust and organic chemicals: an animal model study. Environ Health. 2014
Sadakane K, Ichinose T, Takano H, Yanagisawa R, Koike E, Inoue KI: The alkylphenols 4-nonylphenol, 4-tert-octylphenol and 4-tert-butylphenol aggravate atopic dermatitis-like skin lesions in NC/Nga mice. J Appl Toxicol. 2014
Ichinose T: [Progress of the research on air pollution (PM2.5, Asian sand dust, etc) and allergy]. Arerugi. 2014
Mimura T, Ichinose T, Yamagami S, Fujishima H, Kamei Y, Goto M, Takada S, Matsubara M: Airborne particulate matter (PM2.5) and the prevalence of allergic conjunctivitis in Japan. Sci Total Environ. 2014
Yanagisawa R, Koike E, Ichinose T, Takano H: Obese mice are resistant to eosinophilic airway inflammation induced by diesel exhaust particles. J Appl Toxicol. 2013
Honda A, Matsuda Y, Murayama R, Tsuji K, Nishikawa M, Koike E, Yoshida S, Ichinose T, Takano H: Effects of Asian sand dust particles on the respiratory and immune system. J Appl Toxicol. 2014
Liu B, Ichinose T, He M, Kobayashi F, Maki T, Yoshida S, Yoshida Y, Arashidani K, Takano H, Nishikawa M, Sun G, Shibamoto T: Lung inflammation by fungus, Bjerkandera adusta isolated from Asian sand dust (ASD) aerosol and enhancement of ovalbumin-induced lung eosinophilia by ASD and the fungus in mice. Allergy Asthma Clin Immunol. 2014
Sadakane K, Ichinose T, Takano H, Yanagisawa R, Koike E: Effects of oral administration of di-(2-ethylhexyl) and diisononyl phthalates on atopic dermatitis in NC/Nga mice. Immunopharmacol Immunotoxicol. 2014
Ren Y, Ichinose T, He M, Song Y, Yoshida Y, Yoshida S, Nishikawa M, Takano H, Sun G, Shibamoto T: Enhancement of OVA-induced murine lung eosinophilia by co-exposure to contamination levels of LPS in Asian sand dust and heated dust. Allergy Asthma Clin Immunol. 2014
Song Y, Ichinose T, Morita K, Nakanishi T, Kanazawa T, Yoshida Y: Asian sand dust causes subacute peripheral immune modification with NF-κB activation. Environ Toxicol. 2013
He M, Ichinose T, Song Y, Yoshida Y, Arashidani K, Yoshida S, Liu B, Nishikawa M, Takano H, Sun G: Effects of two Asian sand dusts transported from the dust source regions of Inner Mongolia and northeast China on murine lung eosinophilia. Toxicol Appl Pharmacol. 2013
Tanaka M, Takano H, Fujitani Y, Hirano S, Ichinose T, Shimada A, Inoue KI: Effects of exposure to nanoparticle-rich diesel exhaust on 8-OHdG synthesis in the mouse asthmatic lung. Exp Ther Med. 2013
He M, Inoue K, Yoshida S, Tanaka M, Takano H, Sun G, Ichinose T: Effects of airway exposure to di-(2-ethylhexyl) phthalate on allergic rhinitis. Immunopharmacol Immunotoxicol. 2013
Tanaka M, Aoki Y, Takano H, Fujitani Y, Hirano S, Nakamura R, Sone Y, Kiyono M, Ichinose T, Itoh T, Inoue K: Effects of exposure to nanoparticle-rich or -depleted diesel exhaust on allergic pathophysiology in the murine lung. J Toxicol Sci. 2013
He M, Ichinose T, Yoshida S, Takano H, Nishikawa M, Sun G, Shibamoto T: Induction of immune tolerance and reduction of aggravated lung eosinophilia by co-exposure to Asian sand dust and ovalbumin for 14 weeks in mice. Allergy Asthma Clin Immunol. 2013
Sadakane K, Ichinose T, Takano H, Yanagisawa R, Inoue K, Kawazato H, Yasuda A, Hayakawa K: Organic chemicals in diesel exhaust particles enhance picryl chloride-induced atopic dermatitis in NC/Nga mice. Int Arch Allergy Immunol. 2013
Yanagisawa R, Warabi E, Inoue K, Yanagawa T, Koike E, Ichinose T, Takano H, Ishii T: Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure. J Biochem. 2012
He M, Ichinose T, Yoshida S, Takano H, Nishikawa M, Mori I, Sun G, Shibamoto T: Aggravating effects of Asian sand dust on lung eosinophilia in mice immunized beforehand by ovalbumin. Inhal Toxicol. 2012
Yoshida S, Takano H, Nishikawa M, Miao H, Ichinose T: Effects of fetal exposure to urban particulate matter on the immune system of male mouse offspring. Biol Pharm Bull. 2012
Yasuda A, Inoue K, Sanbongi C, Yanagisawa R, Ichinose T, Tanaka M, Yoshikawa T, Takano H: Dietary supplementation with fructooligosaccharides attenuates allergic peritonitis in mice. Biochem Biophys Res Commun. 2012
He M, Ichinose T, Yoshida S, Yamamoto S, Inoue K, Takano H, Yanagisawa R, Nishikawa M, Mori I, Sun G, Shibamoto T: Asian sand dust enhances murine lung inflammation caused by Klebsiella pneumoniae. Toxicol Appl Pharmacol. 2012
Ding N, Kunugita N, Ichinose T, Song Y, Yokoyama M, Arashidani K, Yoshida Y: Intratracheal administration of fullerene nanoparticles activates splenic CD11b+ cells. J Hazard Mater. 2011
Inoue K, Yanagisawa R, Koike E, Nakamura R, Ichinose T, Tasaka S, Kiyono M, Takano H: Effects of carbon black nanoparticles on elastase-induced emphysematous lung injury in mice. Basic Clin Pharmacol Toxicol. 2011